MODIFICATION OF TOXIC ACTION OF KNOWN CYTOSTATICS BY THE COMBINED APPLICATION OF A NEW DERIVATIVE COLCHAMIN K-48 ON STRAIN OF SARCOMA-45 (23-26)

DOI:

Дата публикации статьи в журнале: 2020/08/20

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 76, Том: 5, Страницы в выпуске: 23-26

Автор: Enikeeva Z.M.
, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Автор: Kobilov O.R.
, Tashkent Medical Academy , Tashkent

Анотация: A study of the antitumor activity of cisplatin and cyclophosphamide in an experiment on the tumor strain of sarcoma-45 in the late period after inoculation showed that the preparations show moderate activity from 60 to 80%, but a number of serious side effects are revealed in animals. The combined use of these drugs with a new derivative of colchamine - K-48, which has an immunomodulating effect and stimulates the proliferation of hematopoietic progenitor cells in the experiment, leads to a decrease in their toxic effects and also increases antitumor activity.

Ключевые слова: antitumor activity, chemotherapy toxicity,colchamine derivative,hematopoietic stem cells,sarcoma-45,

Данные для цитирования: Enikeeva Z.M. Kobilov O.R. . MODIFICATION OF TOXIC ACTION OF KNOWN CYTOSTATICS BY THE COMBINED APPLICATION OF A NEW DERIVATIVE COLCHAMIN K-48 ON STRAIN OF SARCOMA-45 (23-26) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2020/08/20; 76(5):23-26.

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