Номер части:
Журнал
ISSN: 2411-6467 (Print)
ISSN: 2413-9335 (Online)
Статьи, опубликованные в журнале, представляется читателям на условиях свободной лицензии CC BY-ND

STUDYING THE POSSIBILITY OF REDUCING TOXIC EFFECTS OF CHEMOTHERAPY USING THE NEW DERIVATIVE KOLCHAMIN K-48 ON STRAIN OF SARCOMA — 180 (19-23)



Науки и перечень статей вошедших в журнал:
DOI:
Дата публикации статьи в журнале: 2020/08/20
Название журнала: Евразийский Союз Ученых, Выпуск: 76, Том: 5, Страницы в выпуске: 19-23
Автор: Enikeeva Zulfia Makhmudovna
Tashkent, Antineoplastic Drugs RSNPMTSOiR MH RUz, Doctor of Biological Sciences, Professor
Автор: Kobilov Odiljon Rustamovich
Tashkent, Department of Oncology, Tashkent Medical Academy (TMA), Assistant
Автор:
, ,
Анотация: Studies on an experimental tumor strain of sarcoma-180 in BALB / c mice showed that the combined use of cisplatin and vincristine with a new derivative of colchamine K-48 increases their own antitumor activity, while reducing the toxic effects of the treatment. In addition, this combined use of well-known cytostatics with a new drug made it possible to eliminate the death of experimental animals caused by their toxic effects and reduce such side effects as weight loss and spleen, as well as increase the level of leukocytes.
Ключевые слова: antitumor activity   chemotherapy toxicity   colchamine derivative   hematopoietic stem cells   sarcoma- 180                 
Данные для цитирования: Enikeeva Zulfia Makhmudovna Kobilov Odiljon Rustamovich . STUDYING THE POSSIBILITY OF REDUCING TOXIC EFFECTS OF CHEMOTHERAPY USING THE NEW DERIVATIVE KOLCHAMIN K-48 ON STRAIN OF SARCOMA — 180 (19-23) // Евразийский Союз Ученых. Медицинские науки. 2020/08/20; 76(5):19-23.

Список литературы: 1.Agzamova N.A., Enikeeva Z.M., Ibragimov A.A., Abdirova A.Ch., Tillyashaykhov M.N. The study of new derivatives of colchicine K-26 and K-26-B on a solid Ehrlich tumor, sarcoma 180 and Walker's carcinosarcoma in comparison with the activity of a number of drugs // Eurasian Oncological Journal. - 2019. –V.7. - No. 2. –P.30-36. 2.Alieva D.A., Enikeeva Z.M., Karpysheva I.V. The study of toxicity and biological properties of a new compound acting on antibody-forming cells // Eurasian Oncological Journal. - 2017. –V.5. - No. 4. –P.513-517. 3.Balenkov O.Yu. The study of the antitumor effect of new biologically active chloroethylamine analogues of colchicine and colchamine . Diss ... cand. biol. sciences. – Tashkent, 1998. –144 p. 4.Balenkov O.Yu., Enikeeva Z.M., Sultanova D.Sh. Studying the effect of new derivatives of colchicine and colchamine on the number of endogenous colony forming units in the spleen // Chemistry of Natural Compounds. -1999. –№ 1. –P.160162. 5. Crawford J, Dale DC, Lyman GH. Chemotherapy ‐ induced neutropenia. Risks, consequences, and new directions for its management // Cancer. - 2004. –V.100. - V.2. –P. 228-237. 6.Enikeeva Z.M., Balenkov O.Yu., Alieva D.A., Agzamova N.A., Ibragimov A.A. Study of the effect of drugs K42, K-48 and Decocin on the level of CFU // Problems of Oncology. Mat. VIII All- Russian . congress of oncologists. 2013. –T.1 (59). –№ 3. –P. 6061. 7.Enikeeva Z.M., Ibragimov A.A. A new class of cytostatics with stimulation of colony forming units on the spleen ( CFUs ). - Tashkent, “ Fan va texnologiya ”, 2016. - p 173. 8.Kamyshov S.V. The mechanisms of immuneimpaired patients with ovarian cancer receiving chemotherapy, and their dynamics against the background of immunotherapy // Eurasian Oncology Journal, -2018 -P.563-576 9.Kamyshov S.V., Nishanov D.A., Pulatov D.A., Yuldasheva N. Sh. Izuchenie markerov apoptoza, proliferacii i angiogeneza u bol'nyh rakom jaichnika, poluchivshih soprovoditel'nuju immunoterapiju [The study of markers of apoptosis, proliferation and angiogenesis in patients with ovarian cancer who received accompanying immunotherapy]. // Zlokachestvennye opuholi [Malignant tumors], 1. 2017, -P.84-91 10.Kamyshov S.V., Pulatov D.A., Akhmedov O.M., Saidova K.A., Aliyeva D.A. The effect of extracorporeal immunopharmacotherapy on intracellular metabolism in patients with cervical cancer // Eurasian Oncological Journal. 2018 -P. 551- 562 11. Kamyshov S.V., Pulatov D.A., Nishanov D.A., Yuldasheva N.S., Yusupova N.B. Znachimost'ocenki molekuljarno-biologicheskih onkomarkerov v soprovoditel'noj immunoterapii pri rake shejki matki [Significance of the assessment of molecular biological tumor markers in accompanying immunotherapy for cervical cancer]. Onkologija i radiologija Kazahstana [Oncology and radiology of Kazakhstan], -V.2 -P.45- 48 12. Kamyshov S.V., Pulatov D.A., Nishanov D.A., Yuldasheva N.Sh. The effect of the expression level of tumor markers on the results of treatment of patients with cervical cancer who received accompanying immunotherapy // Eurasian Oncological Journal. 2017. -T. 5 (1), -P. 68-76 13. Kamyshov S.V., Pulatov D.A., Yuldasheva N.S. Ispol'zovanie metodov gravitacionnoj hirurgii krovi v kompleksnom lechenii bol'nyh rakom jaichnika [The use of gravitational blood surgery methods in the complex treatment of patients with ovarian cancer]. Vestnik Nacional'nogo mediko-hirurgicheskogo centra im. NI Pirogova BB Bulletin of the National Medical and Surgical Center after Ni Pirogov], 2017. -V.12 (1), P.52-56. 14. Kamyshov S.V., Pulatov D.A., Yuldasheva N.Sh., Balenkov O.Yu. Study of the effect of immunotherapy on peroxidation processes in the accompanying treatment of cervical cancer // Eurasian Oncological Journal 7 (4), P.60-66 15.Kamyshov S.V., Pulatov D.A., Yusupova N.B., Niezova Sh.Kh. The state of immunoreactivity of patients with cervical cancer on the background of extracorporeal immunopharmacotherapy // Bulletin of the National. medical surgeon. center them. N.I. Pirogov. 2018.-T. 13 (1), -P. 98-102 16. Kamyshov S.V., Yuldasheva N.S., Pulatov D.A. Supportive immunotherapy in complex treatment of patiens with oncogynaecological diseases // Cancer Immunology Research, 2013. -P. 158-161 17. Lyman GH Guidelines of the National Comprehensive Cancer Network on the Use of Myeloid Growth Factors with Cancer Chemotherapy: A Review of the Evidence // JNCCN. - 2005. –V.3. –P.557-571. 18. Pulatov D.A., Ibragimov Zh.M., Kamyshov S.V. Comparative assessment of the toxicity of treatment of patients with chemoresistant colorectal cancer // Oncology and Radiology of Kazakhstan 44 (2), 2017 -C. 58-61 19. Sharipov F.K., Balenkov Yu.O., Kireev G.V. The dynamics of free radical oxidation in the tissue of a strain of sarcoma-45 as an indicator of the interaction of the tumor and the body // Oncology. - 2005. –T.51. №2. –C.227-230.


Записи созданы 442

Похожие записи

Начните вводить, то что вы ищите выше и нажмите кнопку Enter для поиска. Нажмите кнопку ESC для отмены.

Вернуться наверх