THE ACTIVITY OF ANTIOXIDANT ENZYMES AND THE EXPRESSION OF THEIR GENES IN THE RAT BRAIN AFTER INJECTING OF VINDEBURNOL IN THE MULTIPLE SCLEROSIS MODEL (8-11)

DOI: 10.31618/ESU.2413-9335.2020.3.72.638

Дата публикации статьи в журнале: 2020/04/15

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 72, Том: 3, Страницы в выпуске: 8-11

Автор: Mendzheritsky Alexander Markovich
Doctor of Biology, FSBEI HE "Don State Technical University", Rostov-on-Don

Автор: Zhukova Marina Valeryevna
, FSBEI HE "Don State Technical University", Rostov-on-Don

Автор: Safronova Larisa Dmitrievna
, FSBEI HE "Don State Technical University", Rostov-on-Don

Анотация: The article presents the results of a study on the effectiveness of vindeburnol, a structural analogue of the cerebral vasodilator vincamine, in the model of multiple sclerosis. The drug was injected subcutaneously in rats after modeling experimental allergic encephalomyelitis at a dose of 20 μg/kg, from the first manifestation of a neurological deficit over the next 10 days. In the somatosensory cortex of animals, the activity of superoxide dismutase, glutathione peroxidase and glutathione reductase, as well as the expression level of the SOD1, GPX4, GPX6 and GSR genes using real-time polymerase chain reaction were studied. It was found that vindeburnol does not affect the expression of the SOD1 gene, as well as the activity of superoxide dismutase, while increasing the expression of the GPS4, GPS6 and GRS genes, which determines the increased activity of glutathione peroxidase and glutathione reductase in rats in the model of multiple sclerosis.

Ключевые слова: multiple sclerosis, activity of antioxidative biocatalysts,gene expressions,vindeburnol,

Данные для цитирования: Mendzheritsky Alexander Markovich Zhukova Marina Valeryevna Safronova Larisa Dmitrievna . THE ACTIVITY OF ANTIOXIDANT ENZYMES AND THE EXPRESSION OF THEIR GENES IN THE RAT BRAIN AFTER INJECTING OF VINDEBURNOL IN THE MULTIPLE SCLEROSIS MODEL (8-11) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2020/04/15; 72(3):8-11. 10.31618/ESU.2413-9335.2020.3.72.638

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