STUDYING THE POSSIBILITY OF REDUCING TOXIC EFFECTS OF CHEMOTHERAPY USING THE NEW DERIVATIVE KOLCHAMIN K-48 ON STRAIN OF SARCOMA — 180 (19-23)

DOI:

Дата публикации статьи в журнале: 2020/08/20

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 76, Том: 5, Страницы в выпуске: 19-23

Автор: Enikeeva Zulfia Makhmudovna
Doctor of Biological Sciences, Professor, Antineoplastic Drugs RSNPMTSOiR MH RUz, Tashkent

Автор: Kobilov Odiljon Rustamovich
Assistant, Department of Oncology, Tashkent Medical Academy (TMA), Tashkent

Анотация: Studies on an experimental tumor strain of sarcoma-180 in BALB / c mice showed that the combined use of cisplatin and vincristine with a new derivative of colchamine K-48 increases their own antitumor activity, while reducing the toxic effects of the treatment. In addition, this combined use of well-known cytostatics with a new drug made it possible to eliminate the death of experimental animals caused by their toxic effects and reduce such side effects as weight loss and spleen, as well as increase the level of leukocytes.

Ключевые слова: antitumor activity, chemotherapy toxicity,colchamine derivative,hematopoietic stem cells,sarcoma- 180,

Данные для цитирования: Enikeeva Zulfia Makhmudovna Kobilov Odiljon Rustamovich . STUDYING THE POSSIBILITY OF REDUCING TOXIC EFFECTS OF CHEMOTHERAPY USING THE NEW DERIVATIVE KOLCHAMIN K-48 ON STRAIN OF SARCOMA — 180 (19-23) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2020/08/20; 76(5):19-23.

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