INFLUENCE OF SUPPORTING IMMUNOTHERAPY ON OXIDATIVE PROCESSES AND ANTIOXIDANT PROTECTION SYSTEM IN CERVICAL CANCER PATIENTS (18-23)

DOI: 10.31618/ESU.2413-9335.2019.1.60.18-23

Дата публикации статьи в журнале: 2019/04/21

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 60, Том: 1, Страницы в выпуске: 18-23

Автор: Kamishov Sergey Viktorovich
MD, PhD, Senior Researcher, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Автор: Tillyashaykhov Mirzagaleb Nigmatovich
, Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Анотация: The indices of induced H2O2 chemical luminescence (CL), lipid peroxidation (LP) products and enzyme antioxidant protection (AP) system in the blood of 95 patients with cervical cancer of II-III stages who received concomitant extracorporeal immunopharmacotherapy (EIPT) were studied. All the patients received complex treatment which included polychemotherapy, surgery, and radiotherapy. The level of chemical luminescence serum in patients with cervical cancer was several times higher than the normal values. The content of lipid peroxidation products in red blood cells of patients and the activity of glutathione-dependent enzymes were initially high. After extracorporeal immunopharmacotherapy the intensity of those processes was significantly reduced. The immunotherapy has also increased the activity of catalase and superoxide dismutase. In cervical cancer patients, the main disease and chemoradiation can increase the content of hydroperoxides in the body causing the imbalance in lipid peroxidation / antioxidant protection system. Extracorporeal immunopharmacotherapy as supporting therapy allows to reduce this imbalance significantly.

Ключевые слова: antioxidant protection, lipid peroxidation,plasmapheresis,cervical cancer,extracorporeal immunopharmacotherapy (EIPT),

Данные для цитирования: Kamishov Sergey Viktorovich Tillyashaykhov Mirzagaleb Nigmatovich . INFLUENCE OF SUPPORTING IMMUNOTHERAPY ON OXIDATIVE PROCESSES AND ANTIOXIDANT PROTECTION SYSTEM IN CERVICAL CANCER PATIENTS (18-23) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2019/04/21; 60(1):18-23. 10.31618/ESU.2413-9335.2019.1.60.18-23

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