Номер части:
ISSN: 2411-6467 (Print)
ISSN: 2413-9335 (Online)
Статьи, опубликованные в журнале, представляется читателям на условиях свободной лицензии CC BY-ND


Науки и перечень статей вошедших в журнал:
DOI: 10.31618/ESU.2413-9335.2019.1.60.18-23
Дата публикации статьи в журнале: 2019/04/21
Название журнала: Евразийский Союз Ученых, Выпуск: 60, Том: 1, Страницы в выпуске: 18-23
Автор: Kamishov Sergey Viktorovich
Tashkent , Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, MD, PhD, Senior Researcher
Автор: Tillyashaykhov Mirzagaleb Nigmatovich
Tashkent , Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan,
, , Professor, Doctor of Medical Sciences
Анотация: The indices of induced H2O2 chemical luminescence (CL), lipid peroxidation (LP) products and enzyme antioxidant protection (AP) system in the blood of 95 patients with cervical cancer of II-III stages who received concomitant extracorporeal immunopharmacotherapy (EIPT) were studied. All the patients received complex treatment which included polychemotherapy, surgery, and radiotherapy. The level of chemical luminescence serum in patients with cervical cancer was several times higher than the normal values. The content of lipid peroxidation products in red blood cells of patients and the activity of glutathione-dependent enzymes were initially high. After extracorporeal immunopharmacotherapy the intensity of those processes was significantly reduced. The immunotherapy has also increased the activity of catalase and superoxide dismutase. In cervical cancer patients, the main disease and chemoradiation can increase the content of hydroperoxides in the body causing the imbalance in lipid peroxidation / antioxidant protection system. Extracorporeal immunopharmacotherapy as supporting therapy allows to reduce this imbalance significantly.
Ключевые слова: antioxidant protection   lipid peroxidation   plasmapheresis   cervical cancer   extracorporeal immunopharmacotherapy (EIPT)                 
Данные для цитирования: Kamishov Sergey Viktorovich Tillyashaykhov Mirzagaleb Nigmatovich . INFLUENCE OF SUPPORTING IMMUNOTHERAPY ON OXIDATIVE PROCESSES AND ANTIOXIDANT PROTECTION SYSTEM IN CERVICAL CANCER PATIENTS (18-23) // Евразийский Союз Ученых. Медицинские науки. 2019/04/21; 60(1):18-23. 10.31618/ESU.2413-9335.2019.1.60.18-23

Список литературы: 1. Aksenova V.M. (2005) Laboratory Diagnostics of Endogenous Intoxication Syndrome. Perm: Medicine (in Russian). 2. Andreyeva L., Kozhemyakin L., Kishkun A. (1988) Modification of lipid peroxide determination method in the test with thiobarbituric acid.Laboratory Practice, 11: 41-43 (in Russian). 3. Arslanova D.R., Antoneyeva I.I., Abakumova T.V., Sidorenko E.G., Voronova O.S. (2011) Antioxidant protection enzymes in tumor tissue with cervical cancer]. Siberian OncoJ, 1:13. 4. Harutyunyan A., Dubinina E., Zybina H. (2000) Methods of assessment of free-radical oxidation and antioxidant activity of the body. SPb.:Commercial Publishing House «Folio» (in Russian). 5. Barsukov V., Chesnokova N. (2008) Activation of lipid peroxidation and failure of antioxidative system in the development of structural and functional disorganization of breast tissue in the area of neoplasia. Russian J Onco, 3:31-32. 6. Bondar T., Lankin V., Antonovskiy V. (1989) Recovery of organic hydroperoxide glutathione peroxidase and glutathione-S-transferase: the influence of substrate structure. Reports of the Academy of Science of USSR, vol. 304, 1: 217-220. 7. Cherdyntseva N.V., Klisho E.V., Kondakova I.V. (1998) A comparative assessment of the ability of tumor-associated and peritoneal macrophages of mice to produce active forms of oxygen. Immunol, 2:3942(in Russian). 8. Curtsinger JM, Gerner MY, Lins DC, Mescher MF. 2007. Signal 3 availability limits the CD8 T cell response to a solid tumor. J Immunol 178:6752-6760. 9. Danilova L.A. (2003) Handbook of laboratory methods of research. St. Petersburg: Piter (in Russian). 10. Dimant I.N., Sharipov F.K., Murathodzhaev N.K. et al. (1992) Oxidation processes and tumor growth. Tashkent: Ibn SinaPublishing and PrintingAssociation, 155 p. (in Russian). 11. DiSaia P., Creasman W. (eds.). (2007) Clinical gynecologic oncology, Mosby Elsevier. 12. Dubinina E. (1989) The biological role of superoxidanion radical and superoxide dismutase in body tissues.Successes of modern biology, 108(4): 3-18 (in Russian). 13. Dubinina E.E. (2001) The role of reactive forms of oxygen as signaling molecules in the metabolism of tissues under oxidative stress. Questions of medical chemistry, 47(6): 561-581(in Russian). 14. GoroshinskayaI., Kachesova P., Nerodo G., Kalabanova E., Shalashnaya E., Surikova E., Nemashkalova L., Neskubina I. (2011) A comparative study of oxidation of proteins and lipids in the blood plasma of patients with cervical cancer with and without metastases. Palliative medicine and rehabilitation, 1: 45-49(in Russian). 15. Gorozhanskaja E.G. (2010) Free radical oxidation and mechanisms of antioxidant protection in a normal cell and in case of tumor diseases (lecture). Clinical laboratory diagnostics, 6: 28-44(in Russian). 16. Gushchin I.S.(1987) Experimental validation of extracorporeal immunopharmacotherapy. In: Gushchin I.S., Leskov V.P., Prozorovskij N.S., Pisarev V.M. Topical of issues immunopharmacotherapy.– Мoscow:Medicine, pp. 71-76(in Russian). 17. Gutteridge J.M., Halliwell B.(2000) Free radicals and antioxidants in the year 2000. A historical look to the future.Ann N Y Acad Sci,899:136-147. 18. Karpishchenko A. (1999) Medical laboratory technologies and diagnostics: Handbook in 2 vol.SPb.: Intermedika, vol. 1. (in Russian). 19. Kohen R., Nyska A. (2002) Oxidation of biological systems: oxidative stress phenomena, antioxidatives, redox reactions, and methods for their quantification. Toxicol Pathol.Nov-Dec; 30(6): 620-650. 20. Kolanjiappan K., Manoharan S., Kayalvizhi M. (2002) Measurement of erythrocyte lipids, lipid peroxidation, antioxidatives and osmotic fragility in cervical cancer patients. Clinica Chimica Acta,326 (1-2): 143-149.https://doi.org/10.1016/S00098981(02)00300-5 21. Kostyuchenko A.L. (2000) EfferentTherapy.SPb.: Commercial Publishing House «Folio» (in Russian). 22. Kozlovskaya L., Nikolaev A. (1985) Manual on Clinical Laboratory Methods of Study. Moscow: Medicine (in Russian). 23. Maneo A., Colombo A., Landoni F. (2005) Treatment of stage IIIB cervical carcinoma. A comparison between radiotherapy, concurrent chemo-radiotherapy and neoadjuvant chemotherapy. Minerva Ginecology,57(2): 141-152. 24. Manju V., Kalaivani J. Sailaja, Nalini N. (2002) Circulating lipid peroxidation and antioxidative status in cervical cancer patients: a case-control study. Clin Biochem, 35(8):621-625. 25. Manoharan S., Klanjiappan K., Kayalvizi M. (2004) Enhanced Lipid peroxidation and impaired enzymatic antioxidative activities in the erythrocytes of the patients with cervical carcinoma.Cell Mol Bio Lett,9(4A):699-707. 26. Ray G., Husain S.A. (2002) Oxidants, antioxidatives and carcinogenesis Indian. J Exp Biol, 40(11): 1213-1232. 27. Rosenberg S., Restifo N., Yang J., Morgan R., Dudley M. (2008) Adoptive cell transfer a clinical path to effective cancer immunotherapy. Nature Reviews Cancer, 8:299-308. 28. Sharipov F.K., Kireev G.V., Koloyarova N.E. et al. (2002) The study of lipid peroxidation of blood serum in cancer patients. Journal of theoretical and clinical medicine, 3:82-85. 29. Smirnov V.V., Karpishchenko A.I., Kushlinskij N.E. et al. (2002) Determination of free-radical oxidation of lipids in thyroid tissues with nodal euthyroid goiter and thyroid cancer. Clin Lab Diagnostics, 10:9.

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