THE INFLUENCE OF CONCOMITANT IMMUNE PHARMACOTHERAPY ON ANTIOXIDANT DEFENSE SYSTEM IN PATIENTS WITH CERVICAL CANCER (44-48)

DOI:

Дата публикации статьи в журнале: 2018/04/16

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 48, Том: 1, Страницы в выпуске: 44-48

Автор: Kamishov S.V.
, Republican Specilized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Автор: Pulatov D.A.
, Republican Specilized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Автор: Enikeeva Z.M.
, Republican Specilized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent

Анотация: The level of H2O2-induced chemiluminescence (CHL), product lipoperoxidation (LP) and the state of enzymatic antioxidant protection (AP) of the system was studied in 95 patients with cervical cancer stage II-III, who received accompanying extracorporeal immunopharmacotherapy (EIPT). The content of LP products in patients' erythrocytes and the activity of glutathione-dependent enzymes were initially high. After EIPT, the intensity of these processes was significantly reduced. Immunotherapy increased the activity of catalase and superoxide dismutase. In СС(cervical cancer) patients, the underlying disease and chemoradiotherapy can increase the content of hydroxide in the body, causing an imbalance in the LP/AP system. EIPT as a concomitant therapy can significantly reduce this imbalance.

Ключевые слова: glutathione-s-peroxidase (HSP), glutathione-s-reductase (GR),glutathione-s-transferase (GST),catalase,chemoluminescence,lipid peroxidation (LP),plasmapheresis (PP),cervical cancer (СС),extracorporeal immunopharmacotherapy (EIPT),

Данные для цитирования: Kamishov S.V. Pulatov D.A. Enikeeva Z.M.. THE INFLUENCE OF CONCOMITANT IMMUNE PHARMACOTHERAPY ON ANTIOXIDANT DEFENSE SYSTEM IN PATIENTS WITH CERVICAL CANCER (44-48) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2018/04/16; 48(1):44-48.

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