Номер части:
Журнал
ISSN: 2411-6467 (Print)
ISSN: 2413-9335 (Online)
Статьи, опубликованные в журнале, представляется читателям на условиях свободной лицензии CC BY-ND

REVERSION MUTATIONS IN BRCA1 AND BRCA2 AND RESISTANCE TO PARP INHIBITORS AND PLATINUM (41-44)



Науки и перечень статей вошедших в журнал:
DOI: 10.31618/ESU.2413-9335.2019.2.69.483
Дата публикации статьи в журнале: 2020/01/11
Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 69, Том: 2, Страницы в выпуске: 41-44
Автор: Islamov Khurshid Djamshidovich
PhD, Republican specialized Scientific and Practical Medical Center of Oncology and Radiology of the Ministry of Health of the Republic of Uzbekistan, Tashkent
Анотация: This article discusses mutations in the BRCA1 and BRCA2 genes and resistance to PARP inhibitors
Ключевые слова: PARP inhibitors, BRCA1 and BRCA2 genes,resistance,
Данные для цитирования: Islamov Khurshid Djamshidovich . REVERSION MUTATIONS IN BRCA1 AND BRCA2 AND RESISTANCE TO PARP INHIBITORS AND PLATINUM (41-44) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2020/01/11; 69(2):41-44. 10.31618/ESU.2413-9335.2019.2.69.483

Список литературы: Камышов С.В., Пулатов Д.А., Юлдашева Н.Ш. Изучение роли молекулярно-биологических маркеров опухоли в выборе метода иммунотерапии в сопроводительном лечении рака яичников и рака шейки матки Евразийский онкологический журнал. 2015. № 2 (5). С. 53-60. Камышов С.В., Пулатов Д.А., Юлдашева Н.Ш. Изучение роли экстракорпоральной иммунофармакотерапии в снижении токсических эффектов химиолучевой терапии у пациентов с раком шейки матки Евразийский онкологический журнал. 2015. № 4 (7). С. 28-34. Камышов С.В., Пулатов Д.А., Ахмедов О.М., Саидова К.А., Алиева Д.А., Гильдиева М.С., Нишанов Д.А. Влияние экстракорпоральной иммунофармакотерапии на внутриклеточный метаболизм у пациентов с раком шейки матки Евразийский онкологический журнал. 2018. Т. 6. № 2. С. 551-562. Камышов С.В. Механизмы иммунных нарушенийу пациентов с раком яичников, получающих химиотерапию, и их динамика на фоне иммунотерапии Евразийский онкологический журнал. 2018. Т. 6. № 2. С. 563-576. Камышов С.В., Юлдашева Н.Ш., Салимова Л.Р. Изучение методов экстракорпоральной иммунофармакотерапии в качестве сопровождения химиотерапии у больных раком яичников Онкология и радиология Казахстана. 2010. № 3-4 (16-17). С. 96. Юлдашева Н.Ш., Наврузова В.С., Ахмедов О.М., Умарова Н.А., Камышов С.В. Особенности лечебного патоморфоза опухоли при рентгенэндоваскулярной полихимиотерапии в комплексном лечении рака шейки матки Онкология и радиология Казахстана. 2010. № 3-4 (16-17). С. 96-97. Venkitaraman AR: Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol 4:461-487, 2009 Silver DP, Livingston DM: Mechanisms of BRCA1 tumor suppression. Cancer Discov 2:679684, 2012 Turner N, Tutt A, Ashworth A: Targeting the DNA repair defect of BRCA tumours. Curr Opin Pharmacol 5:388-393, 2005 Evans T, Matulonis U: PARP inhibitors in ovarian cancer: Evidence, experience and clinical potential. Ther Adv Med Oncol 9:253-267, 2017 Pommier Y, O’Connor MJ, de Bono J: Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action. Sci Transl Med 8:362ps17, 2016 Helleday T: The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings. Mol Oncol 5:387-393, 2011 Murai J, Huang SY, Renaud A, et al: Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib. Mol Cancer Ther 13:433-443, 2014 Ashworth A: Drug resistance caused by reversion mutation. Cancer Res 68:10021-10023, 2008 Sakai W, Swisher EM, Karlan BY, et al: Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature 451:1116-1120, 2008 Banda K, et al: Somatic reversion of germline BRCA2 mutation confers resistance to PARP inhibitor therapy. JCO Precis Oncol http://doi.org/10.1200/PO.17.00044 Cheng HH, et al: Polyclonal BRCA2 reversion mutations detected in circulating tumor DNA after platinum chemotherapy in a patient with metastatic prostate cancer. JCO Precis Oncol https://doi.org/10.1200/PO.17.00169 Carneiro B, et al: Acquired resistance to the PARP inhibitor olaparib in BRCA2-associated prostate cancer due to biallelic BRCA2 reversion mutations restoring both germline and somatic loss of function mutations. JCO Precis Oncol http://doi.org/10.1200/PO.17.00176 Perrin-Vidoz L, Sinilnikova OM, Stoppa-Lyonnet D, et al: The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons. Hum Mol Genet 11:2805-2814, 2002 Wang Y, Krais JJ, Bernhardy AJ, et al: RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest 126:3145-3157, 2016 Edwards SL, Brough R, Lord CJ, et al: Resistance to therapy caused by intragenic deletion in BRCA2. Nature 451:1111-1115, 2008 Quigley D, Alumkal JJ, Wyatt AW, et al: Analysis of circulating cell-free DNA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors. Cancer Discov 7:999-1005, 2017 Kondrashova O, Nguyen M, Shield-Artin K, et al: Secondary somatic mutations restoring RAD51C and RAD51D associated with acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma. Cancer Discov 7:984-998, 2017 Gregory JJ, Jr., Wagner JE, Verlander PC, et al: Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells. Proc Natl Acad Sci USA 98:2532-2537, 2001 Xia B, Dorsman JC, Ameziane N, et al: Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet 39:159-161, 2007 Escribano-Díaz C, Orthwein A, Fradet-Turcotte A, et al: A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol Cell 49:872-883, 2013


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