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Журнал
ISSN: 2411-6467 (Print)
ISSN: 2413-9335 (Online)
Статьи, опубликованные в журнале, представляется читателям на условиях свободной лицензии CC BY-ND

A REVIEW OF MODERN IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANT TUMORS (9-21)



Науки и перечень статей вошедших в журнал:
DOI: 10.31618/ESU.2413-9335.2020.6.74.762
Дата публикации статьи в журнале: 2020/06/14
Название журнала: Евразийский Союз Ученых, Выпуск: 74, Том: 6, Страницы в выпуске: 9-21
Автор: YusupbekovA.A.
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Автор: Kamishov S.V.
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Автор: AdilkhodjaevA.A.
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Анотация: Gastrointestinal (GI) cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. There is clearly a significant unmet need for new drugs and therapies to further improve the treatment outcomes of GI malignancies. Immunotherapy is a novel treatment strategy that is emerging as an effective and promising treatment option against several types of cancers. CTLA-4 and PD-1 are critical immune checkpoint molecules that negatively regulate T cell activation via distinct mechanisms. Immune checkpoint blockade with antibodies directed against these pathways has already shown clinical efficacy that has led to their FDA approval in the treatment of several solid tumors including melanoma, non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, and head and neck cancer. This review will summarize the current clinical progress of modern immunotherapy in the field of GI tumors, with a special focus on immune checkpoint blockade.
Ключевые слова: Immunotherapy   Immune checkpoint blockade   PD-1   PD-L1   CTLA-4   Gastrointestinal cancers   Esophageal cancer   Gastric cancer   Colorectal cancer   Pancreatic cancer  
Данные для цитирования: YusupbekovA.A. Kamishov S.V. AdilkhodjaevA.A.. A REVIEW OF MODERN IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANT TUMORS (9-21) // Евразийский Союз Ученых. Медицинские науки. 2020/06/14; 74(6):9-21. 10.31618/ESU.2413-9335.2020.6.74.762

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