A REVIEW OF MODERN IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANT TUMORS (9-21)

DOI: 10.31618/ESU.2413-9335.2020.6.74.762

Дата публикации статьи в журнале: 2020/06/14

Название журнала: Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале, Выпуск: 74, Том: 6, Страницы в выпуске: 9-21

Автор: YusupbekovA.A.
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Автор: Kamishov S.V.
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Автор: AdilkhodjaevA.A.
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Анотация: Gastrointestinal (GI) cancers are a group of highly aggressive malignancies with a huge disease burden worldwide. There is clearly a significant unmet need for new drugs and therapies to further improve the treatment outcomes of GI malignancies. Immunotherapy is a novel treatment strategy that is emerging as an effective and promising treatment option against several types of cancers. CTLA-4 and PD-1 are critical immune checkpoint molecules that negatively regulate T cell activation via distinct mechanisms. Immune checkpoint blockade with antibodies directed against these pathways has already shown clinical efficacy that has led to their FDA approval in the treatment of several solid tumors including melanoma, non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, and head and neck cancer. This review will summarize the current clinical progress of modern immunotherapy in the field of GI tumors, with a special focus on immune checkpoint blockade.

Ключевые слова: Immunotherapy, Immune checkpoint blockade,PD-1,PD-L1,CTLA-4,Gastrointestinal cancers,Esophageal cancer,Gastric cancer,Colorectal cancer,Pancreatic cancer,

Данные для цитирования: YusupbekovA.A. Kamishov S.V. AdilkhodjaevA.A.. A REVIEW OF MODERN IMMUNOTHERAPY IN GASTROINTESTINAL MALIGNANT TUMORS (9-21) // Евразийский Союз Ученых — публикация научных статей в ежемесячном научном журнале. Медицинские науки. 2020/06/14; 74(6):9-21. 10.31618/ESU.2413-9335.2020.6.74.762

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