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CISPLATIN AND ESTRADIOL SEPARATE AND JOINT ACTION ON CATALASE ACTIVITY IN LIVER AND KIDNEY TISSUES OF RATS (12-16)



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DOI: 10.31618/ESU.2413-9335.2019.2.68.439
Дата публикации статьи в журнале: 2019/12/11
Название журнала: Евразийский Союз Ученых, Выпуск: 68, Том: 2, Страницы в выпуске: 12-16
Автор: Yavroyan Zhenya Vaghinak
, Yerevan State University, PhD
Автор: Hovhannisyan Agapi Gevorg
, Yerevan State University, PhD
Автор: Hakobyan Nune Romen
, Yerevan State University, PhD
Анотация: The aim of this research was to explore the catalase activity in some preparations of liver and kidney tissues of female rats after the cisplatin and estradiol separate and joint in vivo action. The results demonstrated the opposite effects of cisplatin and estradiol on catalase activity in case of separate application of drugs: the cisplatin treatment decreases while the estradiol increases the enzyme activity in both studied tissues. The joint action of cisplatin and estradiol leads to partial recovery of baseline value of catalase activity. Estradiol can soften the toxicity of cisplatin by regulating the amount of ROS by activating antioxidant enzyme catalase. The obtained results may be helpful for explaining the estradiol attenuating effects in case of its joint use with cisplatin
Ключевые слова: oxidative stress  cisplatin  estradiol  antioxidant enzymes  catalase            
Данные для цитирования: Yavroyan Zhenya Vaghinak Hovhannisyan Agapi Gevorg Hakobyan Nune Romen . CISPLATIN AND ESTRADIOL SEPARATE AND JOINT ACTION ON CATALASE ACTIVITY IN LIVER AND KIDNEY TISSUES OF RATS (12-16) // Евразийский Союз Ученых. Биологические науки. 2019/12/11; 68(2):12-16. 10.31618/ESU.2413-9335.2019.2.68.439



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